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Can the Focusrite Scarlett interfaces run in "Standalone Mode"?

Unlike the Focusrite Saffire range of FireWire Audio Interfaces, the Scarlett 8i6 and 18i6 cannot currently run in Standalone Mode. They may pass audio from their analogue inputs to their analogue outputs, through means of Direct Monitoring if MixControl is set up to do so (as it is by default), but this is not a properly supported Standalone Mode.