I've installed Saffire on my PC, but audio playback still comes out my PC's internal speakers/soundcard. How do I route audio to the Saffire instead?

Open 'Sounds and Audio Devices' from the main Control Panel. Once open, you will see several tabs labeled 'Volume, Sounds, Audio, etc'. Select 'Audio' and set Saffire as your Default Device Change these options from Built-In Audio to Saffire. System Output routes system sounds such as alerts, while Default Output routes audio out of CoreAudio applications.